Cancer biology is broad and complex, as the causes and controls for cancer span a diverse range of biological processes, including cell cycle, epigenetics, angiogenesis and immunology. BioLegend provides solutions for advancing all aspects of cancer research, from elucidating the basic science of tumorigenesis to the development of novel immunotherapies. Find antibodies, multiplex assays, in vivo reagents, and resources to investigate individual research areas or connect multiple concepts.
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Angiogenesis
Angiogenesis is the formation of new blood vessels that supply oxygen and nutrients to cells and tissues. Angiogenesis inhibitors are commonly used as cancer treatments because tumors that lack circulatory support have difficulty growing and spreading.
Browse products for angiogenesis.
Cancer Biomarkers
Cancer biomarkers are molecules or proteins detectable in blood, tissues, or bodily fluids that indicate the presence or progression of cancer. Biomarkers like PD-L1, carcinoembryonic antigen (CEA), and lactate dehydrogenase can be used to assess the condition of the cancer and its response to treatment.
Browse products for cancer biomarkers.
Epigenetics
Epigenetics is the study of the mechanisms that control DNA compaction and the accessibility of genes to transcriptional machinery. Aberrant modifications of DNA and histones, as well as dysfunction of histone deacetylases (HDACs), have been associated with tumor development.
Browse products for epigenetics.
Apoptosis and Tumor Suppressors
Tumor suppressors are proteins that inhibit cell growth through mechanisms like cell cycle arrest, apoptosis induction, and blocking cell survival signaling pathways. Well characterized tumor suppressors include PTEN, Rb, and p53 – mutations in the genes that encode these proteins have been associated with cancers.
Browse products for apoptosis and tumor suppressors.
Cell Cycle
The cell cycle controls the replication of cells, and its checkpoints are strictly regulated to prevent abnormal cell proliferation. Proteins like cyclins, cyclin-dependent kinases, and p53 play important roles in cell cycle progression or arrest, and their dysfunction can be associated with tumor growth.
Browse products for cell cycle research.
Immuno-oncology and Immunotherapy
Immuno-oncology refers to the development of immunotherapies, which are immune-based treatments, for combating cancer. These include chimeric antigen receptor (CAR) T cells engineered to recognize cancer cells, checkpoint inhibitors like anti-PD-1 and anti-CTLA-4 antibodies, cytokines like interleukins and interferons, and therapeutic vaccines that prime the immune system to attack cancer cells. Immunotherapies have shown clinical efficacy in treating cancers, which has spurred the growth of immuno-oncology research.
Browse products for immuno-oncology and immunotherapy.
Characterize biomarkers – Measure cancer markers in biological samples with ELISAs and LEGENDplex™ multiplex assays that can be preassembled or customized to include specific targets of interest.
Learn more about: LEGENDplex™ | ELISAs
Phenotype cancer cells – Explore a diversity of tools for phenotyping cancer cells, including an unmatched library of trusted flow cytometry antibodies, Maxpar® Ready antibodies that can be metal-labeled and used for CyTOF®, and TotalSeq™ oligonucleotide-conjugated antibodies for simultaneous proteome and transcriptome analysis.
Learn more about: Flow Cytometry | Maxpar® Ready Antibodies | TotalSeq™
Advance immunotherapy research – Study the roles of cytokines in combating tumor growth with highly stable recombinant proteins, and test strategies for stimulating anti-cancer immune responses in in vivo and ex vivo models with bioactive GoInVivo™ antibodies.
Learn more about: GoInVivo™ | Recombinant Proteins
Study protein and epigenetic modifications – Utilize phospho-specific antibodies to detect activation of signaling proteins and transcription factors involved in tumorigenesis, and characterize epigenetic modifications associated with cancer development using Go-ChIP-Grade™ antibodies.
Learn more about: Protein Phosphorylation | Go-ChIP-Grade™ Antibodies
Webinar videos
Application of BioLegend’s Tools to Explore Bone Cell Differentiation and Bone Cancer
Explore how BioLegend researchers elucidated mechanisms on bone cell differentiation, bone homeostasis, and bone cancer using our research tools, including antibodies, recombinant proteins, and chemical probes.
Cancer Neoantigens as Targets for Natural and Therapeutic Anti-Tumor Responses
This webinar, presented by Dr. Robert Schreiber, addresses how mouse and human cancers have been used to identify therapeutically useful tumor neoantigens.
Cell Signaling in Cancer: New Targets, New Hope
BioLegend proudly sponsors the webinar "Cell Signaling in Cancer: New Targets, New Hope", where a panel of experts discuss how cancer cells communicate and manipulate signaling pathways, and how this communication can be intervened for new cancer therapeutics.
Fighting Cancer from Multiple Angles: Exploring RANK-RANKL, and PD-L1 in mouse melanoma models
Miguel Tam, Senior Manager, Product Realization and Marketing, discusses in vitro models for characterizing melanoma RANK-RANKL interactions, such as cell migration, intracellular signaling, and immunofluorescence microscopy.
Protocols
Whether you need a guide for a particular workflow or want to learn a new technique, BioLegend can provide you with detailed and validated protocols for a range of applications, including flow cytometry, ELISAs, western blot, cell isolation, proteogenomics, and much more. Looking for help on a specific method that isn’t covered in our protocols? Contact our technical service for personalized support.
Blog articles
Advancements in using iNKTs for Cancer Immunotherapy
Like their name suggests, NKT cells have characteristics of NK and T cells and express both a T cell receptor complex and many canonical NK cell markers. Read more.
Cancer Immunotherapy and Immune Checkpoint Inhibitors
The development of cancer is a complex process in which the physiological balance of the organism tilts towards dysregulation. Indeed, the term cancer englobes a collection of related diseases… Read more.
Emerging Methods for Battling Cancer - TALEN Gene Editing
The gene-editing enzymes in this case were TALENs, transcription activator-like effector nucleases, which are synthetic restriction enzymes that can be honed to specific DNA sequences… Read more.
Podcast episodes
Antibody Therapies in Cancer
In cancer, it may be beneficial to prevent interaction of “immune checkpoints”, which can inactivate T cells. Learn more with our podcast about some of the more popular antibody and nanobody treatments.
Listen now.
Cancer Checkpoints, ILCs, and Immunity Integration with Dr. Vijay Kuchroo
In our latest podcast, we speak with special guest, Dr. Vijay Kuchroo, covering cancer research, innate lymphoid cells, and the integration of immune cells into multiple systems.
Listen now.
Stephen Hawking, Extending Lifespans, and Scaffolds in Cancer Vaccines
In our new podcast, we discuss the life of Stephen Hawking, new studies to extend lifespans, and how scaffolding in cancer vaccines promotes dendritic cell responses.
Listen now.
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